AKEEGA® (niraparib/abiraterone acetate) HCP

Benefit of 2-in-1

AKEEGA® is the only FDA-approved medication that combines PARPi/NHT into a single dual action tablet¹

Simplified dosing in a once-daily* dual action tablet

2 THERAPIES

1 CO-PAY

1 PRIOR AUTHORIZATION

The recommended AKEEGA® dose is 200 mg niraparib/1,000 mg abiraterone acetate

2-in-1 Dual Action Tablet with niraparib and abiraterone acetate infographic

*AKEEGA^® is indicated with 10 mg prednisone daily.¹

Flexible dosing

AKEEGA®^† offers your patients 2 strengths for dosing flexibility and adjustments as needed¹^‡

Recommended dose: 2 doses of AKEEGA 100mg/500mg + 1 dose of 10mg prednisone

AKEEGA® recommended dose
200 mg/1,000 mg (niraparib/abiraterone acetate) once daily with 10 mg of prednisone daily

Lower strength dose: 2 doses of AKEEGA 50mg/500mg + 1 dose of 10mg prednisone

AKEEGA® reduced-dose options for specific ARs
2 lower-strength (50 mg/500 mg) niraparib/
abiraterone acetate once daily with 10 mg of prednisone daily

-OR-

Lower strength dose: 1 dose of AKEEGA 100mg/500mg + 1 dose of 10mg prednisone

1 regular-strength (100 mg/500 mg) niraparib/
abiraterone acetate once daily with 10 mg of prednisone daily

^†AKEEGA^® is indicated with 10 mg prednisone daily. Patients receiving AKEEGA^® should also receive a GnRH analog concurrently or should have had bilateral orchiectomy.¹

^‡See full Prescribing Information for guidance on dosage modification for adverse reactions with AKEEGA^®.

PILL COUNT vs OLAPARIB

Reduce your patients’ daily pill count with AKEEGA® compared with Lynparza® (olaparib)^1,4§

Recommended daily dosage for FDA-approved PARPi combination therapies that include abiraterone acetate^1,4

AKEEGA® (niraparib/abiraterone acetate) 2 x 100mg/500 mg & 10mg prednisone daily

Lynparza® (olaparib) recommended dose graphic displaying up to 9 pills taken daily

There have been no head-to-head clinical trials comparing the efficacy or safety of AKEEGA® to other PARPi treatments for prostate cancer. No direct evaluation of comparative clinical profiles can be made.

^§Compared with Lynparza^® + abiraterone acetate, AKEEGA^® reduces patients’ daily pill count for patients with BRCAm mCRPC.⁴

AKEEGA® Safety & Dosing Guide

Supportive resource to help manage dosing and ARs in your patients

Download Dosing Guide

Administration

The recommended dose of AKEEGA® is 200 mg niraparib/1,000 mg abiraterone acetate (two 100 mg/500 mg tablets)^1†

AKEEGA^® tablets must be taken orally as a single dose once a day on an empty stomach

Patients should not eat food for at least 2 hours before and for at least 1 hour after taking AKEEGA^®

The tablets must be swallowed whole with water. Advise patients not to crush or chew tablets

If a dose of AKEEGA^® or prednisone is missed, instruct patients to take the dose as soon as possible on the same day and to return to the normal schedule the following day

Extra tablets must not be taken to make up for the missed dose

^†AKEEGA^® is indicated with 10 mg prednisone daily. Patients receiving AKEEGA^® should also receive a GnRH analog concurrently or should have had bilateral orchiectomy.¹

Learn how your patients can
access AKEEGA^®

See results from the MAGNITUDE trial

AR, adverse reaction; BID, twice-daily; BRCAm, BRCA gene mutated; FDA, U.S. Food and Drug Administration; GnRH, gonadotropin-releasing hormone; NHT, novel hormonal therapy; PARPi, poly (ADP-ribose) polymerase inhibitor; QD, once daily.

References:

AKEEGA^® [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.
Schiewer MJ, Goodwin JF, Han S, et al. Dual roles of PARP-1 promote cancer growth and progression. Cancer Discov. 2012;2(12):1134-1149. doi:10.1158/2159-8290.CD-12-0120
Teyssonneau D, Margot H, Cabart M, et al. Prostate cancer and PARP inhibitors: progress and challenges. J Hematol Oncol. 2021;14(1):51. doi:10.1186/s13045-021-01061-x
Data on file. Janssen Biotech, Inc.

AKEEGA® Dosing

Dose adjustments

AKEEGA®
Dosing